4.7 Article

Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 9, Pages 1100-1102

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b719603b

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A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method.

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