4.7 Article

Site isolated base and acid catalyzed azaspirocyclization cascades

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 7, Pages 832-834

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b716568d

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A one-pot, site isolated base (PS-BEMP) and acid (Si-TsOH) catalyzed cyclization cascade to azaspirocyclic molecules is reported; the reaction is simple to perform, atom efficient (water is the only byproduct) and broad in its scope to a diverse range of azaspirocyclic products.

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