4.7 Article

Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 7, Pages 835-837

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b718201e

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Copper(I)-catalysed domino four-component coupling-cyclisation using 2-ethynylbenzaldehydes, paraformaldehyde, secondary amine, and t-BuNH2 in DMF leads to direct and efficient formation of 3-(aminomethyl)isoquinolines in good to high yields.

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