Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 29, Pages 3444-3446Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b801975d
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A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows similar to 100% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements.
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