Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 81, Issue 5, Pages 557-576Publisher
WILEY
DOI: 10.1111/cbdd.12125
Keywords
1,3,4-thiadiazole; antimicrobial; thiadiazole
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The 1,3,4-thiadiazole nucleus is one of the most important and well-known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, and antitubercular agents. The broad and potent activity of thiadiazole and their derivatives has established them as pharmacologically significant scaffolds. In this study, an attempt has been made with recent research findings on this nucleus, to review the structural modifications on different thiadiazole derivatives for various pharmacological activities.
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