Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 83, Issue 3, Pages 272-277Publisher
WILEY
DOI: 10.1111/cbdd.12235
Keywords
antileishmanial activity; Leishmania amazonensis; tetrazole derivatives
Funding
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Programa Estrategico de Apoio a Pesquisa em Saude (PAPES)
- Coordenacao de Aperfeicoamento de Pessoal Docente (CAPES)
- Universidade Federal Fluminense (PROPP-UFF)
- Centro de Estudos e Inovaczo em Materiais Biofuncionais Avancados/UNIFEI
- Rede Mineira de Quimica (RMQ)
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In this research, a series of substituted 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).
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