Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 22, Pages 2193-2194Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b006906j
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Antimalarial compound qinghaosu (1) and its phenyl derivative 2 were reacted with reduced glutathione (GSH) and Fe(II/III) to give, besides other known degradation products, an interesting adduct from a primary C-centered free radical and GSH. Because GSH plays a very important role in the cell cycle, this finding may eventually lead to a new understanding of its mode of action.
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