Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 81, Issue 3, Pages 408-413Publisher
WILEY
DOI: 10.1111/cbdd.12091
Keywords
antibacterial peptides; beta-aminoboronates; beta-aminoboronic acids; boronic acids; Matteson homologation; peptidomimetics; tuberculosis
Funding
- Norwegian Science Council [177568]
- FORNY [203304]
- MABIT
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Medical treatment for tuberculosis is complicated nowadays by the appearance of new multiresistant strains, and therefore, new antibiotics are in great need. Here, we report the synthesis and in vitro testing of a new class of highly selective antimicrobial boron-containing peptidomimetics with compounds exhibiting activity against Mycobacterium tuberculosis at 5g/mL. The new approach developed makes it possible to synthesize variously substituted -aminoboronic acids and their derivatives with a high level of diastereoselectivity.
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