Related references
Note: Only part of the references are listed.Inhibitors of MDM2 and MDMX: a structural perspective
Christiane Riedinger et al.
FUTURE MEDICINAL CHEMISTRY (2009)
Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2-Tumor Protein 53 Protein-Protein Interaction
John G. Allen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Isoquinolin-1-one inhibitors of the MDM2-p53 interaction
Ulli Rothweiler et al.
CHEMMEDCHEM (2008)
Small molecular weight protein-protein interaction antagonists -: an insurmountable challenge?
Alexander Doemling
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft
Scott A. Showalter et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction
Christiane Riedinger et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
Sanjeev Shangary et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
p53 in health and disease
Karen H. Vousden et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold
Ian R. Hardcastle et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding
S Uhrinova et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction
IR Hardcastle et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
BL Grasberger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes
O Schon et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
NMR structure of a complex between MDM2 and a small molecule inhibitor
DC Fry et al.
JOURNAL OF BIOMOLECULAR NMR (2004)
Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation
MA McCoy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Inhibiting the p53-MDM2 interaction:: An important target for cancer therapy
P Chène
NATURE REVIEWS CANCER (2003)