4.4 Article

Understanding Small-Molecule Binding to MDM2: Insights into Structural Effects of Isoindolinone Inhibitors from NMR Spectroscopy

Related references

Note: Only part of the references are listed.
Review Chemistry, Medicinal

Inhibitors of MDM2 and MDMX: a structural perspective

Christiane Riedinger et al.

FUTURE MEDICINAL CHEMISTRY (2009)

Article Chemistry, Medicinal

Isoquinolin-1-one inhibitors of the MDM2-p53 interaction

Ulli Rothweiler et al.

CHEMMEDCHEM (2008)

Review Biochemistry & Molecular Biology

Small molecular weight protein-protein interaction antagonists -: an insurmountable challenge?

Alexander Doemling

CURRENT OPINION IN CHEMICAL BIOLOGY (2008)

Article Chemistry, Multidisciplinary

Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft

Scott A. Showalter et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Chemistry, Multidisciplinary

Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction

Christiane Riedinger et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Multidisciplinary Sciences

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Cell Biology

p53 in health and disease

Karen H. Vousden et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Chemistry, Medicinal

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold

Ian R. Hardcastle et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding

S Uhrinova et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Chemistry, Medicinal

Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction

IR Hardcastle et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Chemistry, Medicinal

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells

BL Grasberger et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes

O Schon et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

LT Vassilev et al.

SCIENCE (2004)

Review Biochemistry & Molecular Biology

Principles of tumor suppression

CJ Sherr

Article Biochemistry & Molecular Biology

NMR structure of a complex between MDM2 and a small molecule inhibitor

DC Fry et al.

JOURNAL OF BIOMOLECULAR NMR (2004)

Article Multidisciplinary Sciences

Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation

MA McCoy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)