Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 182, Issue 3, Pages 928-932Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/315777
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Funding
- NATIONAL CANCER INSTITUTE [R01CA082053, P30CA047904, R01CA075957] Funding Source: NIH RePORTER
- NCI NIH HHS [R01CA75957, P30CA47904, R01CA82053] Funding Source: Medline
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T cell immunity to lyric proteins of herpesviruses is important in host control of infection. We have characterized the cytotoxic T lymphocyte (CTL) response to 5 human herpesvirus 8 (HHV-8) homologues of lyric proteins in HHV-8-seropositive individuals. HLA class I-restricted, CD8(+) CTL responses to greater than or equal to 1 HHV-8 lyric protein were detected in all 14 HHV-8-seropositive study subjects tested, with or without human immunodeficiency virus type 1 (HIV-1) infection, but not in any of 5 HHV-8-seronegative individuals. Seven of these study subjects with both HHV-8 and HIV-1 infection had greater anti-CTL reactivity to glycoprotein H (open-reading frame 22) than did the 7 study subjects infected only with HHV-8, Moreover, there was a strong, inverse correlation between HIV-1 load and glycoprotein H-specific CTL lysis in the study subjects infected with both viruses. CTL reactivity to HHV-8 lyric proteins may be involved in host control of HHV-8-related diseases, such as Kaposi's sarcoma.
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