Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 75, Issue 3, Pages 277-283Publisher
WILEY
DOI: 10.1111/j.1747-0285.2009.00942.x
Keywords
2-aminopyrrole; aminoacetophenone sulfonamides; cyanoacetamides; multicomponent reaction
Funding
- National Institute of Health [GM087617]
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The design of an unprecedented multicomponent reaction to and synthesis of 2-amino-5-ketoaryl pyrroles are described. The compounds (14 examples) can be synthesized by reacting aminoacetophenone sulfonamides, (hetero)aromatic aldehydes, and malonodinitrile or cyanoacetic acid derivatives in one-pot manner. Pharmacophore features and potential applications of this new scaffold are discussed.
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