Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 73, Issue 1, Pages 7-16Publisher
WILEY
DOI: 10.1111/j.1747-0285.2008.00757.x
Keywords
cold adaptation; drug design; drug discovery; molecular modeling; thermolysin
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Zinc containing peptidases are widely distributed in nature and have important roles in many physiological processes. M4 family comprises numerous zinc-dependent metallopeptidases that hydrolyze peptide bonds. A large number of these enzymes are implicated as virulence factors of the microorganisms that produce them and are therefore potential drug targets. Some enzymes of the family are able to function at the extremes of temperatures, and some function in organic solvents. Thereby enzymes of the thermolysin family have an innovative potential for biotechnological applications.
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