Journal
BIOLOGICAL PSYCHIATRY
Volume 47, Issue 5, Pages 380-390Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(99)00290-5
Keywords
schizophrenia; genetics; endophenotype; evoked potentials; P300; siblings
Categories
Funding
- NIMH NIH HHS [MH43880, MH51117] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [P30MH043880, P50MH043880] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Background: Reduced P300 amplitude is a robust finding in patients with schizophrenia, In previous investigations, we reported reductions of specific subcomponents of the auditory oddball P300 that were independent of acute symptomatology and persistent over time, consistent with a trait abnormality To clarify whether these stable deficits represented genetic markers of vulnerability to schizophrenia, event-related brain potentials (ERPs) from patients were compared to those from their own healthy siblings and unrelated control subjects, Methods: Auditory P300 ERPs were acquired from II schizophrenic patients, 12 healthy siblings and 23 matched central subjects. Five P300 subcomponents were identified using current source density measures: frontal, bilateral parietal, and bilateral temporal, Results: Consistent with previous reports, patients had reduced parietal and frontal P300 amplitudes. The healthy siblings of the schizophrenic probands had an isolated reduction of the frontal P300. Conclusions: Frontal P300 amplitude is a potential endophenotypic marker of generic vulnerability to schizophrenia in individuals who otherwise show no evidence of clinical symptomatology. Given the functional interpretation of the frontal P300 as a physiological correlate of cognitive orienting, this supports the hypothesis that impairments of the neural substrate underlying attentional mechanisms are selective indicators of genetic susceptibility to schizophrenia in high-risk individuals. (C) 2000 Society of Biological Psychiatry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available