Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 62, Issue 5, Pages 499-503Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c14-00077
Keywords
bromopyrrole alkaloid; marine sponge; Agelas sp.
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [25860074, 25670043] Funding Source: KAKEN
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Five new bromopyrrole alkaloids, 2-bromokeramadine (1), 2-bromo-9,10-dihydrokeramadine (2), tauroacidins C (3) and D (4), and mukanadin G (5), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1-5 were elucidated on the basis of spectroscopic data and conformational analysis. Mukanadin G (5) has a tricyclic skeleton consisting of a fused tetrahydrobenzaminoimidazole and 2,5-dioxopyrrolidine moieties. Antimicrobial activities of 1-3, and 5 as well as three related known bromopyrrole alkaloids, keramadine (6), tauroacidin A (7), and taurodispacamide A (8) were evaluated.
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