Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 62, Issue 8, Pages 779-785Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c14-00138
Keywords
Raddeanin A; Anemone raddeana; oleanolic acid; cytotoxicity; histone deacetylase
Funding
- National Natural Science Foundation for the Youth of China [81302647]
- Chunhui Project of Ministry of Education [z2011097]
- Scientific Research Fund of Sichuan Provincial Science and Technology Department
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First, Raddeanin A, a cytotoxic oleanane-type triterpenoid saponin isolated from Anemone raddeana REGEL, was synthesized. Stepwise glycosylation was adopted in the synthesis from oleanolic acid, employing arabinosyl, glucosyl and rhamnosyl trichloroacetimidate as donors. The chemical structure of Raddeanin A was confirmed by means of H-1-NMR, C-13-NMR, IR, MS and elemental analysis, which elucidated the structure to be 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside oleanolic acid. Biological activity tests showed that in the range of low concentrations, Raddeanin A displayed moderate inhibitory activity against histone deacetylases (HDACs), indicating that the HDACs' inhibitory activity of Raddeanin A may contribute to its cytotoxicity.
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