Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 62, Issue 4, Pages 392-394Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c13-00851
Keywords
sponge; Axinyssa sp.; bisabolene-type; cytotoxicity
Funding
- National Museum of Marine Biology and Aquarium
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- National Science Council, Taiwan [NSC 102-2325-B-291-001]
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Chemical investigation of a Formosan sponge Axinyssa sp. has led to the isolation of five nitrogenous bisabolene-type sesquiterpenes 1-5, including two new compounds axinysalines A (1) and B (2). The structures of new compounds were elucidated by analysis of high resolution (HR)-MS and two dimensional (2D)-NMR spectra and comparison of its NMR data with those of known analogues. Compound 1 exhibited moderate to weak cytotoxicity against Molt 4 and K562 cancer cell lines.
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