Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 62, Issue 2, Pages 203-208Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c13-00805
Keywords
Lobophytum crassum; soft coral; cembranoid diterpene; anti-inflammatory
Funding
- Vietnam National Foundation for Science & Technology Development [104.01-2012.37]
- Basic Science Research Program through the National Research Foundation of Korea
- Ministry of Education, Science and Technology, Republic of Korea [20120006681]
- [2012K2A1A2032970]
- National Research Foundation of Korea [2009-0093815] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Nine cembranoid diterpenes 1-9, including four new compounds, crassumols D-G (1-4), were isolated from the methanol extract of the Vietnamese soft coral Lobophytum crassum. Spectroscopic methods were used to elucidate the structures of these compounds. Compound 5 exhibited a potent inhibitory effect on tumor necrosis factor-alpha (TNF alpha)-induced nuclear factor-kappa B (NF-kappa B) transcriptional activation in HepG2 cells and significantly inhibited the mRNA expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in a dose-dependent manner.
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