Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 62, Issue 2, Pages 213-216Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c13-00821
Keywords
marine sponge; Agelas sp.; dimeric bromopyrrole-imidazole alkaloid; nagelamide I; 2,2 '-didebromonagelamide B
Funding
- Naito Foundation
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [25460115, 25670043] Funding Source: KAKEN
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New dimeric bromopyrrole-imidazole alkaloids, nagelamide I (1) and 2,2'-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric bromopyrrole-imidazole alkaloid consisting of two subunits connected with a single bond.
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