Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 61, Issue 6, Pages 662-665Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c12-00877
Keywords
Melastonia sanguineum; flavonoid; advanced glycation end-product; rat lens aldose reductase
Funding
- Korea Institute of Oriental Medicine (KIOM) [K11040, K12040]
- National Research Council of Science & Technology (NST), Republic of Korea [K11040] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A new flavonoid, 2,'' 4 ''-O-diacetylquercitrin (1), along with six known flavonoids (2-7) were isolated from the aerial parts of Melastoma sanguineunz. The structure of the new flavonoid was established by extensive spectroscopic studies and chemical evidence. The inhibitory effects of isolated compounds (1-7) on advanced glycation end-products (AGEs) formation and rat lens aldose reductase (RLAR) in vitro were examined. Of the tested compounds, compound 1 was the strongest inhibitor of AGEs, with an IC50 of 11.46 +/- 0.44 mu m. In the RLAR assay, all tested compounds exhibited greater inhibitory effects on RLAR than that of a positive control, 3,3-tetramethyleneglutaric acid (10(50)=28.8 +/- 1.5 mu m); compound 1 exhibited the strongest RLAR-inhibitory activity, with an IC50 of 0.077 +/- 0.003 mu m.
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