Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 61, Issue 6, Pages 631-636Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c13-00040
Keywords
quinolone derivative; antitumor; topoisomerase I; molecular docking
Funding
- Natural Science Foundation of Zhejiang Province [Y2100908]
Ask authors/readers for more resources
A novel series of quinolone derivatives (6a-n) were designed and synthesized, and their biological activities were evaluated as potential antitumor topoisomerase I (Top I) inhibitors. Among these compounds, 6j exhibited the most potent antitumor activities against multiple cancer cell lines. Docking simulation was performed to insert compound 6j into the crystal structure of DNA-Top I to determine the probable binding model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available