Journal
JOURNAL OF CLINICAL ONCOLOGY
Volume 18, Issue 1, Pages 102-105Publisher
W B SAUNDERS CO
DOI: 10.1200/JCO.2000.18.1.102
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Purpose: This study expands the existing limited data as to whether patients developing clinically significant paclitaxel-induced hypersensitivity reactions can continue to be treated with this important antineoplastic agent and how such retreatment might be undertaken. Patients and Methods: More than 450 patients received paclitaxel, either as a single agent or in a combination regimen, for a female pelvic malignancy in the Gynecologic Oncology Program of the Cleveland Clinic Cancer Center from January 1995 through December 1998. Results: Of the more than 450 patients, 44 (approximately 9%) developed at least one episode of a clinically relevant hypersensitivity reaction to the cytotoxic drug. All 43 individuals (plus an additional four patients referred to our center after having previously experienced a severe paclitaxel-associated hypersensitivity reaction at. another institution) who were retreated with paclitaxel were ultimately able to receive the agent. Five patients required treatment with a standardised desensitization regimen, developed by our group, to successfully receive paclitaxel, Discussion: On the basis of this large single-institution study of paclitaxel-associated hypersensitivity reactions, we conclude that with appropriate precautions essentially all individuals experiencing these reactions can be safely treated with this agent. (C) 2000 by American Society of Clinical Oncology.
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