Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 60, Issue 12, Pages 1599-1601Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c12-00785
Keywords
marine sponge; order Verongida; bromotyrosine alkaloid; tyrokeradine
Funding
- Akiyama Life Sience Foundation
- Suhara Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Four new bromotyrosine alkaloids, tyrokeradines C-F (1-4), have been isolated from Okinawan marine sponges of the order Verongidae. The structures of 1-4 were elucidated on the basis of spectroscopic data. Tyrokeradines C (1) and D (2) are new bromotyrosine alkaloids possesing an imidazole ring, while tyrokeradines E (3) and F (4) are new bromotyrosine alkaloids possesing a cyano group.
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