Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 60, Issue 11, Pages 1458-1460Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c12-00487
Keywords
Penicillium; marine-derived fungus; alkaloid; penicinoline
Funding
- National Natural Science Fundation of China [30973627, 41176120]
- Promotive research fund for excellent young and middle-aged scientisits of Shandong Province [BS2010HZ027]
- Public Projects of State Oceanic Administration [2010418022-3]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0944]
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One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. ghq208. The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds (2, 3) exhibited moderate cytotoxicities against the HepG2 cell line with IC50 values of 11.3 and 13.2 mu m, respectively.
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