Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 60, Issue 10, Pages 1324-1328Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c12-00482
Keywords
Tinospora sagittata; Menispermaceae; clerodane diterpenoid; nitric oxide
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Chemical investigation on the roots of Tinospora sagittata resulted in the isolation of three novel cis-clerodane diterpenoids, tinospinosides D, E, and tinospin E, together with two known compounds, columbin and columbin glucoside, and their structures were determined by extensive spectroscopic analyses, chemical reactions and computer-assisted calculations. The inhibitory activity of the isolated compounds and their chemical derivatives on nitric oxide production in lipopolysaccharide and interferon-gamma activited J774.1 macrophage-like cells was also evaluated.
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