Journal
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Volume 2, Issue 12, Pages 2815-2820Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b001644f
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Ursodeoxycholic acid (UDCA) was ground with a variety of organic compounds using a vibrational mill. Only when either phenanthrene or anthrone was used did powder X-ray diffraction and thermal analysis data indicate that a specific interaction developed with UDCA in the ground mixture. From fluorescence and infrared spectroscopic data, inclusion complex formation with UDCA was suggested during the co-grinding process. The stoichiometry of the inclusion compounds of UDCA-phenanthrene/anthrone was evaluated as a 1:1 molar ratio. Interestingly, no complexes could be obtained by the coprecipitation method, which was conventionally applied for the preparation of inclusion complex of bile acids. Consequently, except when the co-grinding process was performed with either phenanthrene or anthrone, UDCA did not form an inclusion complex.
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