Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 60, Issue 1, Pages 160-163Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.60.160
Keywords
cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase
Funding
- National Dong Hwa University
- National Museum of Marine Biology and Aquarium [100100101, 100200311]
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University [00C-0302-05]
- Taiwan Department of Health Clinical Trial and Research Center of Excellence [DOH 101-TD-B-111-004]
- National Science Council, Taiwan [NSC 100-2325-B-291-001, 99-2323-B-291-001, 98-2320-B-291-001-MY3]
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Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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