Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 59, Issue 7, Pages 834-838Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.834
Keywords
Smgassum yezoense; plastozuinone; peroxisome proliferator-activated receptor gamma agonist; Brown algae; Sargassacea
Funding
- Ministry of Commerce, Industry and Energy (MOCIE) [RTI05-01-02]
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Four new plastoquinones, together with two known compounds, sargahydroquinoic acid and sargaquinoic acid, were isolated from the brown alga, Sargassum yezoense collected from the eastern coast of Korea. The structures of these compounds were elucidated based on spectroscopic analyses including NMR and MS. Their structures designated as meroterphenol A (1), B (2), C (3) and D (4) were characterized by a 6-methyl-1,4-benzohydroquinone moiety with an oxygenated diterpenoic acid chain. Meroterphenols A-D showed potent activation effects on peroxisome proliferator-activated receptor gamma (PPAR gamma).
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