Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 59, Issue 9, Pages 1194-1196Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.1194
Keywords
Mexican propolis; phenylallylflavanone; preferential cytotoxicity; PANG-1 cell
Funding
- Ministry of Health and Welfare for the Third-Term Comprehensive 10-Year Strategy for Cancer Control
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Two new phenylallylflavanones, (2R,3R)-6-11-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]pinobanksin (1) and (2R,3R)-6-11-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-l-yllpinobanksin 3-acetate (2) were isolated from a methanolic extract of Mexican propolis. Their structures were elucidated with spectroscopic analysis. Both compounds (1, 2) exhibited preferential cytotoxic activity against PANC-1 human pancreatic cancer cells in a nutrient-deprived medium with the concentration at which 50% cells died preferentially in NDM (PC50) values of 17.9 mu M and 9.1 mu M, respectively.
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