Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 59, Issue 2, Pages 287-290Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.287
Keywords
tetrahydroisoquinoline alkaloid; proteasome; chymotrypsin-like activity; marine sponge
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18032033, 19310140]
- Naito Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Grants-in-Aid for Scientific Research [19310140, 18032033] Funding Source: KAKEN
Ask authors/readers for more resources
Salsolinol (1), a tetrahydroisoquinoline alkaloid, was isolated from the marine sponge Xestospongia cf. vansoesti collected in Indonesia as a proteasome inhibitor, along with three salsolinol derivatives, norsalsolinol (2), cis-4-hydroxysalsolinol (3), and trans-4-hydroxysalsolinol (4). Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC50 values of 50 and 32 mu g/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 mu g/ml.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available