Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 59, Issue 3, Pages 353-358Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.353
Keywords
cladieunicellin; eunicellin; soft coral; Cladiella; cytotoxicity; superoxide anion
Funding
- NMMBA [99200321, 99200322]
- NDHU
- APORC
- NSYSU [98C031702]
- Taiwan Department of Health Clinical Trial Research Center of Excellence [DOH 99-TD-B-111-004]
- Health Cancer Research Center of Excellence [DOH-99-TD-C-111-005]
- National Science Council, Taiwan [NSC 99-2323-B-291-001, 98-2320-B-291-001-MY3, NSC 98-2113-M-110-002- MY3]
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Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.
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