Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 59, Issue 8, Pages 1048-1050Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.1048
Keywords
Menella; sesquiterpenoid; gorgonian; hydroxylindestrenolide; enantiomer; cytotoxicity
Funding
- National Museum of Marine Biology and Aquarium [100100101, 100200311]
- National Dong Hwa University
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University [98C031702]
- Taiwan Department of Health Clinical Trial and Research Center of Excellence [DOH 100-TD-B-111-004]
- National Science Council, Taiwan [NSC 99-2323-B-291-001, 98-2320-B-291-001-MY3]
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(-)-Hydroxylindestrenolide (1), an enantiomer of the known sesquiterpenoid, (+)-hydroxylindestrenolide (2), was isolated from a gorgonian coral identified as Menella sp. The structure, including the relative stereochemistry of 1 was established by spectroscopic methods and by comparison the spectral and physical data with those of 2. Sesquiterpenoid 1 exhibited marginal cytotoxicity toward HL-60 and K562 leukemia tumor cells, and displayed a weak inhibitory effect on superoxide anion generation at a concentration of 10 mu g/ml by human neutrophils.
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