Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 59, Issue 5, Pages 653-656Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.653
Keywords
Daphne aurantiaca; flavonoid; RAW 264.7 macrophage; nitric oxide
Funding
- NCET Foundation
- NSFC [30725045]
- Ministry of Science and Technology, China [2009ZX09311-001, 2008ZX09308-005]
- Shanghai Leading Academic Discipline Project [B906]
- Scientific Foundation of Shanghai China [09DZ1975700, 09DZ1971500]
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Chemical examination of the methanolic extract from the stem bark of Daphne aurantiaca led to the isolation of three new flavonoids (1-3), and 29 known flavonoids. All 32 compounds were isolated for the first time from Daphne aurantiaca. The isolates were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compounds 21 and 24 showed potent inhibitory activities against the production of NO with IC50 values of 0.006 and 0.076 mu M, respectively.
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