Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 58, Issue 4, Pages 516-520Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.516
Keywords
chromeno[2,3-d]pyrimidine; cyclohexane-1,3-dione; barbituric acid; aldehyde
Funding
- Research Council of Shahid Beheshti University
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A simple and one-pot synthesis of new chromeno[2,3-d]pyrimidine-triones by a three-component condensation reaction of barbituric acids, aldehydes and cyclohexane-1,3-diones in refluxing ethanol in the presence of p-toluenesulfonic acid (p-TSA) for 3-10 h is reported. Two cyclohexane-1,3-diones, four barbituric acids and six substituted aldehydes were chosen for the library validation. Prominent among the advantages of this new method are operational simplicity, good yields and easy work-up procedures employed.
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