Journal
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
Volume -, Issue 22, Pages 4069-4074Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b005577h
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The binding of 4-methylimidazole (mim) to cytochrome c (cyt c) has been studied by H-1 NMR spectroscopy. The kinetic and thermodynamic parameters for the reaction were calculated. The assignment of a number of signals has led to the determination of the magnetic susceptibility tensor of mim-cyt c. It turned out that the orientation of the imidazole ring of mim was different from that of Him in Him-cyt c. This difference was due to the steric interaction between the 4-methyl and the surrounding peptides in the heme cavity. The pseudocontact and contact shifts of the four heme methyl groups in mim-cyt c were calculated. The hyperfine shift pattern and heme electron structure of mim-cyt c were compared with those of native cyt c and Him-cyt c.
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