Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 58, Issue 4, Pages 562-564Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.562
Keywords
flutamide; microbial metabolism; Rhodotorula mucilaginosa
Funding
- United States Department of Agriculture [58-6408-2-00009]
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The yeast culture, Rhodotorula mucilaginosa (ATCC 20129) transformed flutamide (1) to three metabolites: 4-nitro-3-(tritluoromethyl)aniline (2), 2-methyl-N-[4-amino-3-(trifloromethyl)phenyl]propanamide (3) and N-[4-amino-3-(trifluoromethyl)phenyl]acetamide (4). The structures were established by spectroscopic methods.
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