Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 58, Issue 5, Pages 769-772Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.769
Keywords
cyclodextrin; dissolution; powder X-ray diffraction; sealed-heating; inclusion complex
Funding
- Ministry of Education, Culture, Sports, Sciences and Technology (Monbukagakusho) of Japan [21790032, 21590038]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [21590038, 21790032] Funding Source: KAKEN
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A crystalline ternary complex was prepared by sealed-heating of naproxen (NPX) with a flurbiprofen (FBP)/gamma-cyclodextrin (gamma-CD) inclusion complex. The dissolution rates of NPX and FBP in the ternary complex were almost the same, indicating that FBP and NPX from the complex dissolved simultaneously. The ternary CD complex showing a fascinating dissolution property could be a new formulation for combination therapies.
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