Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 58, Issue 2, Pages 242-246Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.242
Keywords
podophyllotoxin; anticancer; osmotic fragility; MTT assay
Funding
- Council of Scientific and Industrial Research-Research Internship (CSIR-RI)
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A series of novel podophyllotoxin (PDT) analogues was synthesized in which the lactone moiety was shifted to C ring. Some of the derivatives were also synthesized with modified A ring. Analogues 23 and 25 exhibited potent in vitro cytotoxicity against colon cancer (CaCO2) cell line. p-Demethylated E-ring analogues exhibited better potency than the corresponding methylated analogues. These analogues showed toxicity comparable to PDT against human erythrocytes albeit at much higher concentrations (100,mu g/ml) than their cytotoxicity values.
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