Journal
JOURNAL OF NATURAL PRODUCTS
Volume 63, Issue 9, Pages 1280-1282Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np000120k
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Anabaenopeptins I (1) and J (2), two new ureido bond-containing cyclic peptides, were isolated from the cultured cyanobacterium Aphanizomenon flos-aquae (NIES-81) as potent carboxypeptidase-A (CPA) inhibitors. The gross structures of 1 and 2 were established by spectroscopic analysis, including the 2D NMR techniques. The absolute configurations of 1 and 2 were determined by spectral and chemical methods. Anabaenopeptins I and J inhibited CPA with IC50 value of 5.2 and 7.6 ng/mL, respectively.
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