Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 58, Issue 9, Pages 1203-1209Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.1203
Keywords
cembrane diterpene; soft coral; Lobophytum crassum; absolute stereochemistry; nitric oxide production
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
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Four new cembrane diterpenes (1-4) and fifteen known cembranoids (5-19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of I, 2, 5 and 6 were elucidated by the application of the modified Mosher's method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of alpha-methylene-gamma-lactone, exhibited the significant effect on NO production.
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