Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 57, Issue 4, Pages 361-367Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.361
Keywords
Helichrysum arenarium; arenariumoside; medicinal flower; tumor necrosis factor-alpha inhibitory activity; Asteraceae; everlasting
Funding
- The Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- Japan Society for the Promotion of Science (JSPS)
- 21st COE Program
- Academic Frontier Project
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The methanolic extract from the flowers of Helichrysum arenarium L. MOENCH was found to show inhibitory effect on tumor necrosis factor-alpha (TNF-alpha 1 ng/ml)-induced cytotoxicity in L929 cells. From the methanolic extract, 50 constituents including four new flavanone and chalcone glycosides named arenariumosides I (1), II (2), III (3), and IV (4) were isolated. The stereostructures of 1-4 were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, naringenin 7-O-beta-D-glucopyranoside (7), apigenin 7-O-beta-D-glucopyranoside (14), apigenin 7-O-gentiobioside (16), and apigenin 7,4'-di-O-beta-D-glucopyranoside (17) significantly inhibited TNF-alpha-induced cytotoxicity in L929 cells at 30 mu m.
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