Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 57, Issue 11, Pages 1246-1250Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.1246
Keywords
Glycosmis parva; glycosparvarine; S-deoxydihydroglyparvin, S-deoxytetrahydroglyparvin; anti-herpes simplex virus activity
Funding
- Royal Golden Jubilee (RGJ) [PHD/0212/2547]
- Thailand Research Fund
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Six acridone alkaloids including a new glycosparvarine (1), three limonoids, and four N-[4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives including two new species, (+)-S-deoxydihydroglyparvin (10) and (+)-S-deoxytetrahydroglyparvin (11), were isolated from the branches and the leaves of Glycosmis parva CRAM collected in the east of Thailand. Antiviral activity evaluation of isolates against herpes simplex virus (HSV) type 1 and 2 disclosed that two acridone alkaloids, glycosparvarine (1) and glycofolinine (4), showed moderate inhibitory activities with 50% effective concentration (EC50) of 348 mu M and 151 mu M respectively; as well, (+)-S-deoxydihydroglyparvin (10) exhibited anti-HSV activity at the lower concentration.
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