Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 57, Issue 12, Pages 1409-1411Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.1409
Keywords
Xylaria sp.; marine-derived fungus; cytochalasin; antibacterial activity
Funding
- Commission on Higher Education
- Thailand Research Fund [RTA5180007]
- Center for Innovation in Chemistry (PERCH-CIC)
- Graduate School, Prince of Songkla University
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A new [11]cytochalasin derivative, xylarisin (1), was isolated from the marine-derived fungus Xylaria sp. PSU-F100 along with six known metabolites: three mellein derivatives (2-4), one pyrone derivative (5) and two carboxylic acids (6,7). The structure and stereochemistry of 1 were determined by NMR and X-ray diffraction analyses. All isolated compounds showed mild antibacterial activity against standard Staphylococcus aureus ATCC 25923 and methicillin-resistant strain.
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