Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 57, Issue 7, Pages 743-746Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.743
Keywords
flavonoid dimer; flavan-chalcone; Sarcandra hainanensis; Chloranthaceae; human immunodeficiency virus-1 integrase inhibition
Funding
- National Natural Science Foundation of China [30530860]
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Two new flavonoid dimers (1, 2) consisting of flavan-chalcone together with three known compounds (3-5) were isolated from the ethanol extract of the whole plants of Sarcandra hainanensis. Their structures were determined by extensive spectroscopic analysis. Human immunodeficiency virus-1 integrase inhibition activities of compounds 1 and 2 were evaluated and they showed weak activities with IC50, at 18.05 and 25.27 mu M, respectively.
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