Journal
JOURNAL OF NATURAL PRODUCTS
Volume 63, Issue 3, Pages 339-343Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np9903090
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Five novel extracellular metabolites with an unprecedented diterpenoid skeleton, 5-[(5-carboxy-2-hydroxy)benzyl]-11-hydroxymethyl-2,5,6,8a,11-pentamethyldodecahydrocyclopenta[a]naphthalene (1), 5-[(5-carboxy-2-hydroxy)benzyl]-11-formyl-2,5,6,8a,11-pentamethyl-dodecahydrocyclopenta[a]naphthalene (2), 5-[(5-carboxy-2-hydroxy)benzyl]-11-carboxy-2,5,6,8a,11-pentamethyl-dodecahydrocyclopenta[a]naphthalene (3), 5-[(5-carboxy-2-hydroxy)benzyl]-11-dihydroxymethyl-2,5,6,8a,11-pentamethyldodecahydrocyclopenta[a]naphthalene (4), and 5-[(5-carboxy-2-hydroxy)benzyl]-11-acetyl-2,5,6,8a-tetramethyldodecahydrocyclopenta[a]naphthalene (5), have been isolated from the culture medium of the terrestrial cyanobacterium Nostoc commune by means of bioguided isolation. The molecules were designated as comnostins A-E. The structures were determined by spectroscopic methods, mainly NMR and mass spectrometry. The relative stereochemistry of comnostin A was confirmed by single-crystal X-ray structure analysis. All comnostins showed antibacterial activities. Additionally, cytotoxic and molluscicidal activities were found for comnostin B.
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