Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 57, Issue 10, Pages 1089-1095Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.1089
Keywords
Cissus sicyoides; flavonoid; benzofuran-type stilbene; cissoside; cissusin; degranulation inhibitor
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Three new flavonoid glycosides (cissosides I, II, and III) and a new benzofuran-type stilbene (cissusin) were isolated from the methanolic extract of the aerial parts of Cissus sicyoides cultivated in Brazil. Their structures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated constituents on the release of beta-hexosaminidase as a marker of degranulation in rat basophilic leukemia (RBL-2H3) cells were examined. Cissusin, flavonols (kaempferol, quercetin), flavones (7,3',4'-trihydroxyflavone, lanceolatin B), pterocarpanes (homopterocarpin), chalcones (isoliquiritigenin, E-7-O-methylpongamol), and tryptanthrin markedly inhibited the release of beta-hexosaminidase.
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