Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 57, Issue 3, Pages 280-282Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.280
Keywords
Muehlenbeckia platyclada; Polygonaceae; flavonoid; superoxide anion generation; neutrophil elastase
Funding
- National Science Council
- National Science Technology Program/Biotechnology and Pharmaceuticals
- National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center
- Center of Excellence for Environmental Medicine [KMU-EM-97-2.1a]
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A new flavonol, morin-3-O-alpha-rhamnopyranoside (1), along with four known flavonols, kaempferol 3-O-alpha-rhamnopyranoside (2), kaempferol 3-O-beta-glucopyranoside (3), quercetin 3-O-alpha-rhamnopyranoside (4) and (+)-catechin (5), were isolated from the methanolic extract of Muehlenbeckia platyclada. The structures of these compounds were determined on the basis of chemical and spectroscopic evidence, as well as acid hydrolysis of the original glycoside. Isolates were evaluated for inhibition of generation of superoxide anion, and inhibition of release of neutrophil elastase. Compound 2 showed moderate inhibition of superoxide anion generation with an IC50 value of 6.11 +/- 0.86 mu g/ml; 1, 3 and 5 inhibited neutrophil elastase release with IC50 values of 3.82 +/- 0.80, 8.61 +/- 1.38 and 4.37 +/- 0.72 mu g/ml, respectively, and were 15-fold more potent than phenylmethylsulfonyl fluoride (PMSF), the positive control, in this anti-inflammatory assay.
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