Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 57, Issue 1, Pages 74-78Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.74
Keywords
synthesis; beta-cyclodextrin; hydroquinone; surface plasmon resonance; saccharide-attached cyclodextrin; doxorubicin
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This paper describes syntheses and doxorubicin-inclusion abilities of beta-cyclodextrin (CyD) derivatives with a hydroquinone alpha-glycoside residue attached at the primary side. The hydroquinone glycoside having an alpha-D-glucosidic or 2-acetamido-2-deoxy-alpha-D-glucosidic linkage became a useful component for providing an alpha-D-glucose- or 2-acetamido-2-deoxy-alpha-D-glucose-beta-CyD conjugate. The surface plasmon resonance analyses of these beta-CyD derivatives for the anticancer agent, doxorubicin, indicated that they had excellent inclusion associations on the order of 10(5)M(-1) for the immobilized doxorubicin.
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