Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 2, Pages 213-216Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.213
Keywords
Rubia cordifolia L.; epoxymollugin; topoisomerase; cytotoxicity
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Activity-directed isolation of the methylene chloride fraction of the roots of Rubia cordifolia L. resulted in the identification of a new epoxymollugin (3) and eight known compounds (1, 2, 4-9). The structures of the compounds were elucidated from chemical and spectroscopic evidence. In addition, their topoisomerase I and II inhibitory activities and cytotoxicities were measured.
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