Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 5, Pages 723-726Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.723
Keywords
flavone; Pterogyne nitens; mycloperoxidase; antioxidant; radical scavenging
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [04/07932-7] Funding Source: FAPESP
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Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox(R).
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