Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 56, Issue 11, Pages 1579-1584Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.1579
Keywords
salting-out taste-masking system; particle size; solubility; lag time; release
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The salting-out taste-masking system is a multiparticulate system consisting of a drug core, a salting-out layer containing salts and water-soluble polymers, and a water-penetration control layer containing water-insoluble materials. The system generates a long lag time (time when released drug is less than 1%) for numbness masking, and a subsequent immediate drug release for high bioavailability. Aiming to contain the system and drubs that cause numbness in oral disintegrating tablets, the system was optimized to reduce the particle size and contain drugs with high water solubility in this study. The amount of coating on the layers, the coating solvent. and the positioning of the components were also optimized. The findings in this study will lead to the provision of numbness-masked oral disintegrating tablets to patients.
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